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Zuo S, Liu T, Li L, Xu H, Guo J, Wang Q, et al

have anti-inflammatory, anti-ischemic and anti-fibrotic effects and inhibit myocardiocyte apoptosis.29,32,42 More recently, it has been reported that they also reduce epicardial fat.43 They also inhibit platelet aggregation and thrombosis.44 In the lungs, rGLP-1 activation conferred protection against lipopolysaccharide-induced acute lung injury.45 In adipose tissue they favor adipocyte differentiation, decreases lipid deposition in white fat and facilitate its conversion to brown fat, as well as thermogenesis and energy consumption29,32,4648

Melanin, the pigment responsible for skin tone, exists in two forms: blackish-brown eumelanin and reddish-yellow pheomelanin

PMID 11692074.

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One mouse study reported no increase in mean lifespan