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Alendronate itself is not a metal ion, so a direct glutathione-alendronate chelation reaction is not the concern

When this happens, the medication may not interact with the bodys receptors the way it was designed to

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Maximal mean increases in QTc of 8.0 msec were observed in one study at a dose of 800 mg Januvia, a mean effect that is not considered clinically important [see Clinical Pharmacology]

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In addition, the rate of pyruvate carboxylation, but not pyruvate decarboxylation, is correlated with the degree of insulin release in rat pancreatic islets [29, 31]