: A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma
The incidence of gastrointestinal adverse events was 72.5% with CagriSema versus 34.4% with placebo, predominantly transient and mild to moderate in severity
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The underlying mechanism generally consists of the oxidation of redox-reacting cysteine and/or tyrosine residues located within or near the active site, which creates intraprotein and interprotein bridges that affect protein function 8,9
Alternatively, the PCE might be compensatory in humans: tirzepatide reduced blood pressure in humans, and this can lead via central mechanisms to a reflective tachycardia (Fras et al
This is not entirely different from previously mentioned subtypes however
