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At only 2% of bodyweight, the brain is relatively small, yet it consumes more than 20% of the body's total energy

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[9,10,11] Acetaminophen-related liver toxicity is responsible for about half of all cases of acute liver failure in the United States.[12] Acetaminophen toxicity is the #1 reason for liver transplants in the USA, and the #2 reason for liver transplants worldwide.[13] This risk is especially high in people who drink alcohol: Check out my article & video on The Hangover Remedy That Can Kill You. In summary: Paracetamol is mean to the liver, and it doesnt take much more than the recommended dose to cause major harm

Schidt et al

10.1007/s40292-024-00630-8 16 DohlmannT

Additionally, high-dose or long-term chemotherapy often induces drug resistance in cancer cells, diminishing therapeutic efficacy and posing a major challenge for chemotherapy