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Mean body weight and BMI in these 579 participants decreased from 109.5 kg to 38.6 kg/m 2 , respectively, at the screening to 101.9 kg and 35.9 kg/m 2 , respectively, at randomization, representing an average 6.9% reduction in body weight after the 12-week intensive lifestyle modification [58]

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Superdex 200 10/300 GL column was used for chromatographic separations