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Diabetes Metab Res Rev 31(3):248255 Vasu S, Moffett RC, Thorens B, Flatt PR (2014) Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress
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in part, it may be seen that it is desirable to concomitantly inhibit PDE-5 and increase production of cGMP by means of different pathways, thereby resulting in optimal therapeutic benefit with minimal adverse effects
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