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Many peptide systems discussed herein have been repeatedly shown to exert robust physiological effects in vivo , often across multiple species, yet lack approved therapeutic analogs or advanced clinical programs despite decades of investigation

242 When GLP-1 binds to GLP-1R on -cells, it activates these cells and promotes the secretion of somatostatin

They tell your brain youre full, slow gastric emptying, and improve how your body handles insulin and blood sugar

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It was the first paper to show the therapeutic potential of GLP-1 (7-37) for treatment of type 2 diabetes (Nathan, Schreiber, Fogel