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This pathway can help patients feel fuller, reduce appetite, slow digestion, and support blood sugar control

The integrated dataset was then clustered, and highly upregulated genes in each cluster (identified by the Wilcoxon rank sum test in Seurat), along with the spatial context of the clusters location in situ, were used to annotate the predominant cell type in each spot

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Nevertheless, important uncertainties remain, including the degree of brain penetrance across individual agents, the relative contributions of central versus peripheral mechanisms, biomarkers of target engagement, and the patient subgroups most likely to benefit