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In direct comparisons, semaglutide at higher doses consistently outperforms dulaglutide for weight outcomes

We refer commenters to the testing results in this rule, as well as the results calculated using the July 2023 Overall Star Rating as reported in the CY 2025 OPPS/ASC final rule with comment period (89 FR 94514 through 94521) which produced similar findings

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Schoenenberger and Monnier reported in the Proceedings of the National Academy of Sciences USA the isolation, sequence determination and synthesis of the active material, identified as the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, and demonstrated that intraventricular infusion of the synthetic compound in rabbits reproduced delta- and spindle-EEG enhancement under double-blind conditions (Schoenenberger & Monnier, 1977)

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If that same patient's A1C rises from 6.2% to 7.1%, crossing the diabetes threshold, Ambetter will cover Ozempic