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The study identified increased proportions of pro-inflammatory and mesenchymal fibroblast subpopulations, elevated p16 protein and SA--galactosidase-positive cells, and enhanced SASP gene expression in keloid tissue

For long-term immune rebalancing with thymosin alpha-1, allow 4 to 8 weeks for the full regulatory T-cell effects to develop

On the contrary, this down-regulation of CRH receptors fails to normalize after mitigation of stress or reduction in CRH levels, perhaps due to abnormal plasticity of the CRH receptors

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