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McKay D, Sookman D, Neziroglu F, Wilhelm S, Stein DJ, Kyrios M,

To be metabolized, B12 is combined with a particular protein made in your stomach, without which the vitamin wont be absorbed into your body

Krishnamoorthy K., Mohan R

Consistent with this, use of a reducing source such as -mercaptoethanol allows reversal of xCT-KO phenotype, as it has been reported couple decades ago by Bannai's group ( in vivo can explain the discrepancy with in vitro phenotype