MTR (methionine synthase) the enzyme that uses 5-MTHF to regenerate methionine from homocysteine requires cobalamin (B12) as its essential cofactor
Cannon RM, Bass DM, Powers SM
10.2131/jts.34.s111 39 TripathiA.PandeyV.SahuA
Its effectiveness depends on the existing cellular machinery and availability of NADPH, making it less responsive to sudden oxidative challenges
[206] Baker published her memoir in 2006, Arnold and Me: In the Shadow of the Austrian Oak

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