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Some effects can be noticed within a few weeks, but it may take longer to observe the full range of benefits

doi: 10.2174/156720106777731118

27 Another study compared a combination oral supplement that included 600 mg/d ALA along with gamma-linolenic acid to a vitamin supplement containing vitamins B1, B6, and B12 over 3 months in 112 patients with moderate to severe CTS.28 Researchers found similar results, with significant pain reduction and improved function in the ALA treatment group with only slightly improved pain reduction in the vitamin B group but with worsened function

While creating 5-MTHF, the body undergoes several biochemical conversions (methylation)