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In a phase 2 study , people who took a 12 mg dose of retatrutide lost an average of 17.5% of their body weight in six months and 24% of their weight in 48 weeks

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This dual action external peptide supply plus stimulation of endogenous upregulation may produce more sustained neurological effects than supplementing a single growth factor alone

Unlike some other peptides in its class, ipamorelin does not significantly boost cortisol or prolactin levels, which helps minimize potential side effects

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