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The CNC domain was originally identified in a Drosophila segmentation gene

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This aligns with the body-first PD subtype theory, suggesting that peripheral initiation may precede CNS involvement (Goedert et al., 2017

Metabolic signals such as ghrelin, insulin or glucagon modulate insulin sensitivity, glucose tolerance, lipid metabolism, vascular hemostasis, and even immune responses 120,121

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