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No evidence supports the safety of continuous long-term use

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Chronic tendon and joint injuries typically follow 6 to 8-week cycles at higher doses

Pharmacy, [online] 10(5), p.106

In patients with syndromes like Laugier-Hunziker and Peutz-Jeghers mucosal melanosis can be diagnosed in high frequencies and in patients with inflammatory skin diseases like lichen planus genital melanosis have been reported (5,7-9)