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It tends to be worst in the first few days after increasing to a new dose and often improves over subsequent weeks as the body adapts

While many previous reports 21 used mouse models with diet-induced obesity, this study employed non-obese mouse models with reduced insulin secretion capacity induced by streptozotocin administration

Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood

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