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Weeks 1-4: 0.10mL 10 units/week Weeks 5-8: 0.20mL 20 units/week Weeks 9-12: 0.30mL 30 units/week After finishing a vial, patients take the 2-month tolerance break.

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Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress

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Extended follow-up studies would identify any delayed adverse effects and establish whether therapeutic benefits persist, diminish, or require continued treatment for maintenance