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Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats

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H 2 O 2 caused approximately over 37% of LDH leakage, while RGD-GHK and sOtx2-GHK attenuated H 2 O 2 -induced LDH release by 12% and 10%, respectively, as shown in Figure 4C