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Symptoms may include: Penile curvature or bending during erection Palpable hardened plaque or nodules Penile pain (especially in early or active phases) Erectile dysfunction Loss of length or girth While some cases stabilize on their own, many men seek treatment when symptoms persist or worsen

The body preferentially uses -tocopherol, and only -tocopherol supplementation can reverse vitamin E deficiency symptoms

Systemic Therapy (Severe / Refractory) Methotrexate (weekly oral/injection), cyclosporine for rapid clearance, acitretin for pustular/erythrodermic types

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Additionally, pretibial myxedema occurs Due to dermal fibroblast stimulation that leads to GAGs deposition in the connective tissue