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This combination can lead to superior glycaemic control compared to either medication alone

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The stress hormone cortisol interferes with sleep quality, promotes muscle breakdown, and directly causes tiredness when chronically elevated

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Patients with PCOS experience excess production of androgens, which disrupts ovulation and leads to irregular menstrual cycles, infertility, acne, excess hair growth, and weight gain ( 1 , 2 )

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Approval: 2010 WARNING: RISK 0F THYROID C-CELL TU MORS See full prescribing information for complete boxed warning (2023)

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281 A more recent study found that GLP-1R expression was increased in hepatocytes from non-alcoholic steatohepatitis liver samples in comparison to healthy livers, implying that GLP-1R signalling plays a role in liver pathology

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