However, it should be recalled that most results obtained so far derive from preclinical studies, and in vivo investigations in humans are thus necessary to fill this gap
A dose escalation was used to help to mitigate the occurrence and severity of nausea, and the nausea events observed were mild or moderate and of short duration
doi: 10.1017/s1461145707008401, Summary Keywords Ficus mucuso , ketamine, neurochemistry alteration, neurodegeneration, oxidative stress, risperidone, schizophrenia Citation Okomolo Moto FC, Diapa Tchiengang J, Kameni Njapdounke JS, Mbom A, Mbeboh Savo F, Aren Arsaa MN, Nezoumne FN, Ndjock SR and Bum EN (2026) Antipsychotic effects of aqueous lyophilisate of Ficus mucuso on ketamine-induced schizophrenia
There is also an observed potential decrease in the activity of enzymes that facilitate the urea cycle
After a review of the totality of information, including all clinical data generated to date for danuglipron and recent input from regulators, Pfizer decided to discontinue development of the molecule