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PMID: 21404916

Further research indicates that combinations of specific compounds, such as icaritin and curcumol, can inhibit PCa progression by modulating the gut microbiota-enriching beneficial taxa, which in turn suppresses DNA methyltransferase 1 expression and activates CD8+ T cell-mediated antitumor immunity (123)

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Crooke, S

2729 Currently, three major signaling proteins including c-Jun N-terminal kinase (JNK), Nrf2, and p53 have been found to be involved in mitochondrial oxidative stress