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NNMTs role is to transfer a methyl group to nicotinamide (vitamin B3), creating 1-methylnicotinamide a reaction that consumes cellular methyl donors and depletes nicotinamide adenine dinucleotide (NAD) stores

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The chart below shows timing considerations for common combinations

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This small molecule compound was developed through sophisticated structure-guided design and binding calculations as part of a systematic effort to create membrane-permeable NNMT inhibitors with enhanced potency and selectivity

The compounded market has grown significantly due to the high cost and periodic shortages of brand-name products