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Next, to test whether spike protein affected CFTR in the ACE2:CFTR co-immunoprecipitate, we incubated the epithelia with the Wuhan-Hu-1 [S1S2] spike protein, and then measured co-immunoprecipitation of ACE2 and CFTR with anti-ACE2 antibody

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Current clinical guidelines for hyperuricemia and gout emphasize a dual approach: (1) acute flare management using nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, or corticosteroids and (2) long-term urate-lowering therapy (ULT) with xanthine oxidase inhibitors (e.g., allopurinol and febuxostat) or uricosurics (e.g., probenecid) (Sattui and Gaffo, 2016)

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