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Some users adopt a 3-month on, 1-month off strategy to prevent desensitization and maintain receptor sensitivity

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Hurd MD, Martorell P, Delavande A, Mullen KJ, Langa KM

This enhances the faces contour, sharpens the profile, and may enhance the appearance of the jawline as well

And fluoride, though controversial in use, has been shown in research to cause hypothyroidism when ingested or used in large amounts