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PMID 11169620

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Mboumi said

Using ex vivo models, metformin treatment significantly inhibited oxidative phosphorylation and glycolysis in treatment nave rectal cancer biopsies, without affecting the real-time metabolic profile of non-cancer rectal tissue

Although it's formed in these organs, it's stored primarily in muscle (including the heart) as well as the brain and even in sperm

[8] With advancing age, there is a decline in proteasome activity in cardiac tissue, which represents a significant mechanism contributing to the increased susceptibility of older organisms to cardiovascular diseases