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Experimental investigations have reported enhanced VEGFR2 phosphorylation together with increased focal adhesion kinase (FAK) activity and downstream ERK1/2 signaling

[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Cole B.F., Kadlubar F.F

The mechanism likely relates to changes in appetite regulation and energy metabolism

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10.1038/s41467-019-12934-8 Nat

Analysis of the microbial composition revealed that metformin treatment increased the abundance of Firmicutes and decreased the abundances of Actinobacteria and Proteobacteria at the phylum level (Fig