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This structural difference leads to variations in their biological activities and potential therapeutic applications

This means sermorelin requires an at least partially functional pituitary to produce any effect, while somatropin does not

Int J Dev Neurosci 55:4148 Zhang K, Lin W, Zhang J, Zhao Y, Wang X, Zhao M (2020) Effect of Toll-like receptor 4 on depressive-like behaviors induced by chronic social defeat stress