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Identification of polymorphisms in the 5-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation

Phase I metabolism must take place in order for the active drug to be formed

The most consistent problem was the near-total absence of human clinical trial data for the proposed injectable routes

Ocular tissues exhibit exceptionally high energy demands: photoreceptors require substantial ATP for phototransduction

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It is not approved for children, and should not be taken alongside other GLP-1 receptor agonists