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For most adults with newly diagnosed type 2 diabetes without cardiorenal disease, metformin plus lifestyle modification remains initial therapy, with GLP-1 agonists as preferred second-line agents

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[1] While the term "bloating" specifically is not listed in the FDA prescribing information, related gastrointestinal symptoms such as abdominal distension and dyspepsia are among the commonly reported side effects with tirzepatide therapy