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"We expect all of them to take note of what could be the potential consequences of their continued behavior," John Kuckelman, Novo Nordisk's group general counsel, told USA TODAY

It demands commitment to lifestyle changes, consistent medication use, and ongoing medical supervision to monitor progress and adjust treatment as needed

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GLP-1RAs have been combined with glucose-dependent insulinotropic agonism, as well as glucagon agonism or amylin analogues to further enhance their metabolic benefits

Body fat distribution changes differ, with men seeing more concentrated midsection reduction and women experiencing more distributed fat loss

The hope is that results will be available for regulators to review by the end of 2025