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It concurrently impairs antioxidant defenses (e.g., by inhibiting catalase) [32] and promotes inflammation by elevating pro-inflammatory cytokine levels and reducing nitric oxide (NO) bioavailability [33]

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If its production is inhibited or limited, as it is with several types of genetic glitches then dysfunction and disease result

Any disruption in this hierarchical structure, such as through mechanical overload or biochemical degradation, can compromise the integrity of the ACL and increase the risk of injury

& Bolt, H