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Administration & Dosage Administration Method Injections are typically administered intramuscularly (IM) or subcutaneously (SQ)

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One gene therapy product, betibeglogene autotemcel (beti-cel), has reached phase 3 clinical trials with promising results in reducing transfusion requirements for patients with transfusion-dependent beta-thalassemia

Due to their localization in the basal ganglia, A 2A R modulates the indirect pathway by modulating gamma-aminobutyric acid (GABA) and glutamate release, both of which are highly involved in the control of voluntary movements [10]