flow semaglutide reduces risk for major kidney disease events in patients with type 2 diabetes FLOW Study Highlights: How Semaglutide

The substantial benefits these medicines provide for diabetes control and weight management typically outweigh temporary side effects

doi: 10.1038/nrendo.2010.123

All of these factors may contribute to increased demands for B vitamins

Other studies have suggested that there is no significant difference in the risk of acute pancreatitis or pancreatic cancer between the two groups when GLP-1RA is used (84, 85)

That same mechanism explains why a small subset of people may experience a temporary reduction in sexual motivation

Furthermore, all three drugs are associated with myelosuppression, nausea, and organ dysfunction, while methotrexate specifically leads to acute renal injury and neurotoxicity 85