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(Wikipedia) In senescent cells (cells that have permanently exited the cellcycle, accumulate damage, and secrete inflammatory factors), FOXO4 expression goes up and helps bind p53 in the nucleus, preventing p53 from driving those cells into apoptosis

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Since maintaining muscle mass is essential for metabolic stability, mobility, and overall health, it is important for individuals on GLP-1 therapy to prioritize resistance training and adequate protein intake to help mitigate these effects

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(2019) 10(Suppl_4):S27583