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Surgery: Indicated for complete structural tears but involves prolonged recovery, scar tissue formation, and variable long-term outcomes in chronic cases

van Baak MA, Hul GB, Toubro S, Astrup A, Gottesdiener KM, DeSmet M, et al

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Such stress-associated -cell states are known to display impaired incretin responsiveness due to reduced GLP1R signaling and diminished cAMP pathway activation (Luo et al., 2013)[Gao], suggesting that inflammatory axes linked to dysbiosis may differentially affect vulnerable -cell subpopulations