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Additionally, there is a third testis-specific Trx reductase, TrxR3, also known as thioredoxin glutathione reductase, which is primarily expressed in germ cells and contains a class I Grx domain [9] (see below)

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[PUBMED Abstract] de Bono JS, Oudard S, Ozguroglu M, et al.: Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial

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Oncogene (2016) 35(8):93951.10.1038/onc.2015.150 36 KodamaHFukudaKPanJMakinoSBabaAHoriSet alLeukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in rat cardiomyocytes