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49 Elevated inflammatory factors in T2D such as IL-6 and interferon- (IFN-) cand bind to their receptors, activate JAK2/STAT3, subsequently upregulates the expression of suppressor of cytokine signaling 3 (SOCS3), which inhibit IRS-1 cascade

doi:10.1073/pnas.1002178107, PMID: 20713697 Adam-Vizi V, Chinopoulos C (2006) Bioenergetics and the formation of mitochondrial reactive oxygen species

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If left unchecked, lipid peroxidation destroys the structural integrity of the mitochondria and triggers a highly inflammatory form of programmed cell death known as ferroptosis, a mechanism heavily implicated in the pathophysiology of ME/CFS

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