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We have previously noted that the peripheral long-term subcutaneous administration of exendin-4 decreased food intake and induced weight loss in both obese and lean control Zucker rats [15]

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Apply a cold compress for the first 5 minutes after injection to reduce bruising, then switch to gentle massage in a circular motion around (not on) the injection site to promote even absorption

Patients should also seek medical attention if headaches are accompanied by concerning symptoms, including: Visual disturbances such as blurred vision, double vision, or vision loss Neurological deficits including weakness, numbness, difficulty speaking, or coordination problems Altered mental status such as confusion, disorientation, or difficulty concentrating Severe nausea and vomiting that prevents adequate hydration or medication adherence Neck stiffness or photophobia (light sensitivity), which may suggest meningeal irritation High blood pressure readings, especially if 180/120 mmHg with headache Additionally, patients should consult their healthcare provider if headaches significantly interfere with daily activities or quality of life, or if over-the-counter analgesics provide insufficient relief

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