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Clinical trials show average weight loss of 15 to 20% or more, making it one of the most effective obesity medications available

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The authors concluded that due to the high prevalence of MTHFR variants and how crucial it is to assure pregnant women get adequate supplementation, L-methylfolate may be the best option to avoid blood folate deficiencies. The study also notes that excessive ingestion of folic acid could mask an undiagnosed B12 deficiency, and that it was unlikely that methylfolate would mask a B12 deficiency in the same way

They help explain why Tirzepatide is studied , not how it should be used

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It works by blocking the reuptake of certain chemicals in the brain called monoamines