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Reference: He J, Zhang X, Ma H

Harsh chemicals like hydroquinone, which have been used historically for skin lightening, can cause side effects such as skin irritation, ochronosis (a bluish-black discoloration), and even increased risk of cancer with prolonged use

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(Symptoms of neuropathies include: tingling, numbness, loss of sensation, burning sensation, loss of balance and co-ordination.) Important notes before taking Actobion (Vitamin B1 / Vitamin B6 / Vitamin B12): Tell your doctor or pharmacist if you are hypersensitive to Vitamin B1, Vitamin B6, Vitamin B12, or any of the other ingredients of this medicine