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In contrast to CFU-e, BFU-e progenitors proliferate slowly [36] and respond to stem cell factor (SCF), interleukin-3 (IL-3), IL-6, and insulin-like growth factor 1 (IGF-1) [36,37,38]
The detoxification against H 2 O 2 in mitochondria occurs mainly through the GSH redox system, including the glutathione peroxidases (Gpxs) and GSH reductases, as well as the presence of peroxiredoxins (Prxs
As we age, glutathione production gradually declines: research consistently shows lower cellular glutathione concentrations in older adults compared to younger adults (Detcheverry et al., 2023)
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