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And the patient populations among studies are different

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Forecasting models often overestimate ROI: Many commercial forecasts fail to account for patient leakage, especially in obesity indications, leading to inflated expectations and missed market realities

ARTN e412710.7759/cureus.4127 (2019)

Lean mass preservation during GLP-1based weight loss: why body composition matters A key translational issue in GLP-1RA-based obesity therapy is that substantial weight loss does not automatically translate into favorable body-composition outcomes