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GPX3 was identified as a potential target, with the highest expression level among the antioxidant enzymes examined in the rat Achilles tendon

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ROS are able to break the double bonds of PUFA, producing malondialdehyde (MDA) [24], the main end-product of membrane lipid peroxidation (LPO)

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In addition to de novo lipid synthesis, the loss of G6PD function also led to impaired NOS2 activity in Ms activated by LPS (61) or by IFN- and infected by Trypanosoma cruzi (62)