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Many patients find significant appetite suppression and early weight loss at this level, though further increases may be needed for optimal results

Concerning the antimalarial mode of action, we proposed that the lead benzylNQ are initially oxidized at the benzylic chain to benzoyl-1,4-naphthoquinones (benzoylNQ) in a heme-catalyzed reaction within the digestive acidic vesicles of the parasite (Figure 1)