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In tumors, persistent ROS elevation increases GSH synthesis and shifts the redox balance, creating a biochemical environment that selectively activates disulfide/diselenide linkers and metal-based GSH-depleting nanoplatforms

3.2.3 Intracellular Deacetylation and Release of Active GSH Once inside the cell, SAG is specifically deacetylated by ubiquitous esterases

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