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A broader 2020 review by Sikiric and colleagues in Gut and Liver frames the compound's proposed GI activity within Robert's cytoprotection and organoprotection model the longstanding physiological framework describing how the gastric mucosa protects itself against injury

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n = 7 mice for vehicle and Palbociclib+ RSL3, n = 5 mice for RSL-3 and n = 6 mice for Palbociclib