Although alanine substitutions of I178 4.60 , L181 4.63 , and F286 6.58 all significantly impair activities of ghrelin and GHRP-6, these residues make distinct extents of contributions
Unlike other ROS, it directly attacks biomolecules, causing extensive cellular damage through processes such as lipid peroxidation and DNA strand breaks [28, 29]
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Posner MI, Dehaene S (1994)
The GliSODin group had significantly lower cellular DNA damage as evidenced by a test called Comet Assay. Also, these findings coincided with reduced blood isoprostane levels, another marker of oxidative stress