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10.1016/j.mce.2014.11.015 60 JinS

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However, as polypeptide drugs, GLP-1RAs are easily hydrolyzed by enzymes in the gastrointestinal environment

38,39 That said, there are also reports of no significant impact of exenatide on BMD or fracture risk in T2D, 40 with subsequent meta-analyses also yielding conflicting outcomes

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[1] These combined actions lead to improved glycemic control and significant weight reduction, with clinical trials in adults without diabetes demonstrating average weight loss of 15-22% of body weight over 72 weeks in the SURMOUNT-1 trial